Mechanism of vinegar cures depression & psychosis

Mechanism of vinegar cures depression & psychosis

          Frank Li   Sep 11 2026

https://blog.creaders.net/user_blog_diary.php?did=NTY4MzA0

During the last century, in Canada, Dr. Abram Hoffer using megadose niacinamide or niacin (He named as Vitamin B3, used in dose of 3g) cured schizophrenia; and the achievement promoted the birth of the Orthomolecular Medicine. 

Now, the therapeutic mechanism was revealed.

Goolge searched AI Overview in Oct 16, 2026

In the key world: niacin, Physiological effects

Niacin (Vitamin B3) acts primarily as a vital precursor to the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which drive core physiological and biochemical functions throughout the body.

Vinegar improved symptoms of depression by rising niacin

In 2024, study reports Daily Vinegar Ingestion Improves Depression and Enhances Niacin Metabolism in Overweight Adults: A Randomized Controlled Trial.

Twice daily oral 2.95 g vinegar icreased niacinamide or niacin (Vitamin B3) by 86% in the metabolites and improved self-reported depression symptomology; which showed that alterations in niacin metabolism may factor into this improvement.

Myself test of the process of Vitamin B3 taking effect

it said that the side effects of B3 are itching and redness of the skin. There are reports describing turning whites into Indian celebrities. In order to verify its safety tolerance, on Jan. 25, 2020, I bought a bottle of B-3 (Niacin), see the photo. I took 500mg x 2 in one time,                    

12:10, Orally took 500mg x 2with water.

12:27, I started to feel a slight hot and itching ...

12:38, Face, forehead, back of neck, outside of arms, were obviously hot, itchy ...

12:48, My thighs were hot and itching. There was a desire to scratch the outside of the arms.

12:50, I start to scratch the back, both sides of the belly. My thighs were obvious hot, itchy, and swollen.

13:05, The hot and itching begin to subside.

14:05, I still have the feeling of hot and itchy.

15:39, The skin of thighs and calves seems to be in slightly overheated water.

17:19, The skin of thighs and calves still felt hot, and the face was hot.

19:01, Only the face was hot, no itching all over the body.

The overall feeling was warm, itchy and was bearable.

Thanks B-3.

Vinegar can treat diseases by improving gut microbiota.

The increasing of the niacin needs the help of gut microbiota or gut bacteria; the  operators at the Human Nutrition Factory. They are taking charge of processing and assembling the ingested food into the necessary nutrients or the basic components of human body that can be absorbed.

In 2023, study reports that Beneficial effect of vinegar consumption associated with regulating gut microbiome and metabolome: Vinegar interacts with gut microbiotaby shifting microbial populations, altering metabolic pathways, and helping regulate gut inflammation. 

Human digestive system - Gut is the second brain in producing 95% of Serotonin, neurons and most neurotransmitters, transplanting gut bacteria from healthy mice cured sick one, transplanting gut bacteria from the mother made new born disease free, and cured kids with autism.

The gut-brain axis or the gut microbiota–brain axis that is composed of the central nervous system, autonomic nervous system, enteric nervous system, endocrine system, immune system, and gut microbiota.

It is a two-way biochemical and neural communication network linking the gastrointestinal tract with the central nervous system.

Dysbiosis (a disturbance in the microbiome balance) has been identified as one of the risk factors for neuropsychiatric illnesses such as depression, anxiety, autism spectrum disorder, Parkinson’s disease, and Alzheimer’s disease.

Therapeutic strategies aimed at the gut microbiota, such as probiotics, dietary modifications, probiotics, and fecal microbiota transplantation, and so forth, became populer for curing incurable diseases. Such as, Parkinson’s  and Alzheimer’s disease.

The interconection of Vingar, psychosis, and niacinamide 

Google by keyword: vinegar , psychosis, niacinamide

AI Overview

Vingar, psychosis, and niacinamide (a form of vitamin B3)intersect primarily through recent scientific findings in metabolomics and historical theories in orthomolecular psychiatry[1, 2]

Here is how these three concepts connect based on clinical research:

1. The Vinegar and Niacinamide Connection

Clinical trials, including a notable study from Arizona State University, discovered that daily liquid vinegar ingestion significantly increases serum niacinamide (nicotinamide) concentrations. [1, 2]

• The Mechanism: Consuming liquid vinegar (acetic acid) upregulates the NAD+ salvage pathway.

• The Result: This metabolic shift caused an average 86% increase in niacinamide levels in participants, which directly correlated with a significant reduction in depressive symptoms. [1, 2, 3]

2. The Niacinamide and Psychosis Connection

The relationship between vitamin B3 (niacin or niacinamide) and psychosis centers on two medical areas:

• The Niacin Flushing Test: Psychiatrists use a skin test with niacin as a biological marker for schizophrenia and psychosis risk. Most healthy individuals experience temporary skin flushing (redness) from niacin. However, a significant subset of individuals with schizophrenia exhibit "niacin blunting"—an abnormally low or absent flushing response caused by disrupted prostaglandin and fatty acid signaling. [1, 2, 3, 4]

• Orthomolecular History: In the 1950s, a movement called orthomolecular psychiatry hypothesized that megadoses of vitamin B3 (niacin or niacinamide) could treat schizophrenia by altering adrenaline metabolism. While modern mainstream medicine treats psychosis with standardized antipsychotic medications, clinical researchers still study a rare "niacin-dependent" subset of psychiatric symptoms, such as severe niacin deficiency (pellagra), which can cause profound hallucinations, delusions, and psychosis. [1, 2, 3, 4]

Summary of the Intersection

Above was the AI Overview

Vinegar can kill virus by increases immune cells in the blood

2019, article Disinfect the Natural Way indicates that human immunity is by immune cells releasing Hypochlorous acid - HOCl kills viruses. So that since the birth of mammals, it is HOCl in functioning immunity.

2020, article Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 reports that a COVID-19 sufferer self-recovered after the increase of immune cells in blood, which persisted for at least 7 d following full resolution of symptoms.

2001, article The effect of cider vinegar on some nutritional and physiological parameters in mice reports that mice were treated with daily oral doses of 0.17, 0.51 and 1.02 ml of the vinegar/kg body weight for 4 weeks. 

Raise immune cells: Hemoglobin (Hb), total erythrocyte counts (TEC) and total leukocyte counts (TLC) were raised in all treated groups. 

Weight reduction: Cider vinegar induced a significant reduction in weight gain in animals treated with 0.51 ml/kg. Others no differences in weight loss. 

Vinegar kille virus by chemically changing the proteins and fats

Jan. 11, 2018, article Does vinegar really kill household germs? said that: ”Vinegar, be it white or malt or rosemary-infused, is about 5 per cent acetic acid. The acid kills bacteria and viruses, by chemically changing the proteins and fats that make up these nasties and destroying their cell structures.”

It can be seen that the virus-killing function of vinegar has a broad spectrum without distinction. Surprisingly, we may Google a lot health benefits of vinegar.

In 2012, article Vitamin B3 May Help Kill Superbugs reports that “Nicotinamide, commonly known as vitamin B3, may help the innate immune system kill antibiotic-resistant staph bacteria, the so-called "superbugs". In lab work done with mice and human blood, researchers found high doses of the vitamin increased the ability of immune cells to kill the bacteria by 1,000 times.”

Vinegar integrating melatonin will be the cure for all

We must follow TCM philosophy to view patient as emotional human from Western medicine viewd as nonhuman assembly; by restores Yin-Yang balance as treatment; then by body needed nutrients repairing ill and aging lesions; thus the cheaper handy dietary supplements will be the cure for all.

Vinegar can kill viruses, increase immune cells; to restore abnormal physiological indicators to normal; while melatonin promotes the regeneration of ill and aging nerve cells; immune cells, and stem cells of kidney failure, to regenerate system.

Vinegar and melatonin can both regulate the gut microbiota or gut bacteria.

My experience, water dilutes 5% vinegar x 18 ml (0.9g pure)/50kg + melatonin x 5-10mg daily once will be cure for all. Two times of vinegar cured my wife and son Covid-19. Vinegar + melatonin cured my wife Parkinson's for 25 years.

In days; I gave up 200-degree reading glasses, weeks; my facial skin rosy smooth, less wrinkles, digestion, energy, hearing, memory, and mental agility, etc., improved; show the renew in blood, vessels, microcirculation, younger 30 years.

Under TCM philosophy, Vinegar can kill all viruses; using it’s alone is able to empty the emergency room of hospitals; Vinegar + melatonin can cure the most diseases to empty hospitals. It is no western medicine made incurable. No Alzheimer's; no diabetes, no psychosis; no Parkinson's, no HIV or AIDS, no stiff-person syndrome, etc., due to the fact that they are curable.